LIPS detection of antibodies to six different HHV-8 protein fragments. Using LIPS, antibodies were evaluated against K8.1-Δ1, K8.1-Δ2, LANA-Δ2, LANA-Δ3, v-cyclin, and ORF65 using 83 sera from a training set. Each symbol represents an individual sample from the training set consisting of 43 controls (CTRL) and 40 KS/HHV-8-infected subjects (KS). Antibody titers are plotted on the y axis using a log10 scale. The 9,000-LU cutoff is shown by the solid lines. A volunteer sample (non-KS) from the training cohort that was found HHV-8 positive by both ELISA and LIPS is included with the KS samples.