FIG. 4.

Heat map representation of patient antibody profiles to the four HHV8 antigens. The titer values for each serum were log₁₀ transformed, and then the titer levels were color coded as indicated by the log₁₀ scale on the right, in which signal intensities range from red to green, indicating high and low titers, respectively. The samples were rank ordered from highest to lowest based on the sum of the antibody titers to the four-antigen panel. The samples on the left are from KS-infected sera. The asterisks mark the samples that were negative or indeterminate for anti-K8.1 and anti-LANA antibodies by ELISA. A volunteer sample (non-KS) from the validation cohort that was found HHV-8 positive by both ELISA and LIPS is denoted by the triangle.