FIG. 12.

Working model for Skn7 participation in the activation of OXR genes. The nuclear localization of Yap1 in an oxidizing environment [Yap1(ox)] leads to a weak interaction with DNA-associated Skn7 via the I428 and V429 residues in the Skn7 receiver domain. The Skn7-Yap1 (DNA) complex recruits a kinase that reinforces the Skn7-Yap1 interaction via serine/threonine phosphorylation of Skn7 (Skn7-S/T∼P). The strong association between Skn7 and Yap1 that is a result of Skn7 phosphorylation is required for the efficient transcriptional activation of OXR genes.