FIG. 7.

Cytokine production. CT and LT strongly inhibit the production of TNF-α but increase the production of IL-12, IL-1β, and IL-6. B cells were stimulated with polyclonal stimuli, including 2.5 μg/ml of CpG ODN 2006, 50 U/ml of IL-2, and 2 μg/ml of anti-Ig MAb, and simultaneously treated with the compounds indicated or left untreated (NT) for 3 days. B-cell culture supernatants from five different donors were collected and analyzed for the presence of the cytokines indicated by ELISA. The error bars indicate standard deviations. The asterisks indicate a statistically significant difference (P < 0.05) between the treatment and control (NT) samples.