TABLE 2.
Antibody responses of mice injected with plasmids pVax-Fc*BoNT/A, pVax-Fc*BoNT/B, and pVax-Fc*BoNT/E, with electrotransfer, as a monovalent or multivalent seruma
| Antigen | Antibody titer at 45 days
|
|
|---|---|---|
| Multivalent | Monovalent | |
| FcBoNT/A | 2,280 ± 648 | 1,759 ± 571 (NS) |
| FcBoNT/B | 1,155 ± 462 | 1,816 ± 845 (NS) |
| FcBoNT/E | 7,876 ± 3,056 | 1,330 ± 377** |
a
Multivalent refers to the coinjection and electrotransfer of three plasmids, pVax-SecEpo-Fc*BoNT/A, pVax-SecEpo-Fc*BoNT/B, and pVax-SecEpo-Fc*BoNT/E. Swiss mice (n = 4) were treated with 40 μg of each plasmid DNA. Antibody titers were determined by ELISA on serum samples at day 45. Results show means ± SEM. **, P < 0.01; NS, no significant difference between the two groups.