TABLE 3.
Association between Lewis blood group phenotypes of the BC children and symptomatic and asymptomatic infections with ETEC expressing different CFs
| CF (toxin ratio) expressed by ETEC | Type of ETEC infection | No. (%) of children with indicated phenotype
|
Pb | |
|---|---|---|---|---|
| Le(a+b−) (n = 41)a | Le(a−b+) (n = 102) | |||
| CFA/I (LT:ST:LT/ST = 0:36:5) | Symptomatic | 7 (17) | 6 (6) | 0.075 |
| Asymptomatic | 9 (22) | 19 (19) | NS | |
| CFA/I group fimbriae (CFA/I, CS14, and CS17) (LT:ST:LT/ST = 8:55:10) | Symptomatic | 11 (27) | 11 (11) | 0.032 |
| Asymptomatic | 13 (32) | 38 (37) | NS | |
| CFA/I group including strains co-expressing CS3 (CFA/I, CS14, CS17, CS1+CS3, and CS2+CS3) (LT:ST:LT/ST = 10:69:18) | Symptomatic | 18 (44) | 16 (16) | <0.001 |
| Asymptomatic | 16 (40) | 47 (46) | NS | |
| CFA/II group (CS3 only, CS1+CS3, and CS2+CS3) (LT:ST:LT/ST = 2:15:12) | Symptomatic | 10 (24) | 5 (5) | 0.002 |
| Asymptomatic | 5 (12) | 9 (9) | NS | |
| CS6 (CS6 only and CS5+CS6 strains) (LT:ST:LT/ST = 3:38:18) | Symptomatic | 8 (20) | 17 (17) | NS |
| Asymptomatic | 9 (22) | 25 (25) | NS | |
a
A total of 143/179 children with Le(a−b+) and Le(a+b−) blood groups had an ETEC infection; we excluded 24 Le(a−b−) and 12 non-ETEC-infected children from this analysis.
b
Statistical analysis was done for the relationship between children with the Le(a−b+) phenotype and children with the Le(a+b−) phenotype. NS, not statistically significant.