Table 1.
ED50 values of GnRH agonists for inositol phosphate production in COS-1 cells transiently transfected with the goldfish A and B GnRH receptor subtypes
| Peptide (common name) | GfA GnRH receptor
|
GfB GnRH receptor
|
||
|---|---|---|---|---|
| ED50, nM | Potency relative to sGnRH | ED50, nM | Potency relative to sGnRH | |
| [Trp7,Leu9]GnRH (sGnRH) | 4.6 ± 0.3 | 1 | 56 ± 20 | 1 |
| [His5,Trp7,Tyr8]GnRH (cGnRH-II) | 0.03 ± 0.01 | 153 | 3.4 ± 2 | 16.5 |
| Mammalian GnRH | 210 ± 69 | 0.02 | 2,850 ± 21 | 0.02 |
| [Ser8]GnRH (sea bream GnRH) | 684 ± 100 | 0.007 | >10,000 | >0.006 |
| [His8]GnRH | 11 ± 3 | 0.42 | >20,000 | >0.003 |
| [Tyr8]GnRH | 4.65 ± 1 | 1 | 640 ± 100 | 0.08 |
| [dArg6,Trp7,Tyr8]GnRH | 0.03 ± 0.01 | 153 | 0.8 ± 0.5 | 70 |
| [His5,dArg6,Leu8]GnRH | 3.3 ± 2 | 1.4 | 630 ± 100 | 0.08 |
| [dArg6,Trp7,Leu8]GnRH | 0.4 ± 0.2 | 11.5 | 21.7 ± 10 | 2.6 |
Data are calculated as the mean of three separate experiments.