TABLE 1.

BKV loads in urine and plasma, plasma creatinine levels, and biopsy results for Israeli RT patients A to F

Patienta	Time (mo) after RT	Viral load (no. of copies per ml)b		Plasma creatinine level (mg/dl)	Biopsy reportd
		Urine	Blood
A (M, 53)	3	2.37 × 105	1.26× 105	1.8	Suspicion of rejection (tubular interstitial nephritis, tubular atrophy); suspicion of viral infection (visible inclusion bodies, infiltrate in medulla)
	8	8.02 × 106	1.73 × 105	2.7
B (M, 74y	10	3.95 × 107	2.48 × 105	3.2	Viral infection (tubular changes with focal tubular atrophy, inclusion bodies with viral particles [determined by electron microscopy])
C (M, 60)	24	3.13 × 108	5.46 × 105	6.1	Viral infection (decoy cells in urine, infiltrate in medulla); tubular changes (medula and glomerulus, BKV-positive inclusion bodies)
	29	3.57 × 108	1.02 × 106	7.5
	34	4.14 × 108	1.64 × 106	7.8
D (F, 14)	84	4.67 × 108	5.34 × 106	7.8	No concurrent biopsy available
E (F, 55)c	3	1.65 × 104		1.1	Support (virus-associated chronic tubulointerstitial nephritis); mild acute cellular rejection; grade 1A focal proliferative glomerulonephritis; focal atrophy of tubules; hyperchromasia of nuclei
	13	1.69 × 105		1.6
	16	3.06 × 108		6.1
	2/51e	3.60 × 107		2.1
F (M, 52)	2	2.70 × 109	Below detection	8.5	Acute tubular necrosis

^aThe information in parentheses represents the patient's sex (F, female; M, male), the patient's age (in years) at the time of the first RT.

^bViral loads (number of copies per ml) were determined by qPCR. Titers in boldface indicate loads near or above the PVAN-predictive thresholds for urine and plasma (19, 35).

^cNo concurrent plasma samples were available for patient E.

^dBiopsy report from a renal biopsy taken at the time of the first patient sample. All of the text refers to that biopsy.

^e2/51, 51 months after the first transplant and 2 months after the second transplant.