TABLE 2.
Distribution of BKV mrNCRR and snvNCRR variants in urine samples or paired plasma and urine samples of RT patients
| Patient-sample no./mo after RT | Plasma clones
|
Urine clones
|
||||||
|---|---|---|---|---|---|---|---|---|
| mrNCRRa
|
snvNCRR variantsb | mrNCRR
|
snvNCRR variants | |||||
| Name | No. | % | Name | No. | % | |||
| A-1/3 | WWL1 | 11 | 85 | 1, 2 | WWL1 | 2 | 20 | 1 |
| WWL2 | 2 | 15 | 3 | WWL2 | 8 | 80 | 1, 2, 3 | |
| A-2/8 | WWL2 | 8 | 80 | 1, 4, 5, 6 | WWL2 | 20 | 84 | 1, 5, 7, 8, 9 |
| V1 | 2 | 20 | 1 | V2 | 1 | 4 | 1 | |
| V3 | 2 | 8 | 1 | |||||
| V4 | 1 | 4 | 1 | |||||
| B-1/10 | WWL2 | 9 | 56 | 1, 2, 3, 4, 5 | WWL2 | 3 | 33 | 1 |
| V1 | 4 | 25 | 1, 2 | V1 | 4 | 44 | 1, 3 | |
| V2 | 2 | 13 | 1, 2 | V3 | 1 | 11 | 2 | |
| V3 | 1 | 6 | 1 | V4 | 1 | 11 | 1 | |
| C-1/24 | WWL1 | 3 | 33 | 1 | WWL1 | 6 | 67 | 1, 2 |
| V2 | 3 | 33 | 1, 2 | V1 | 1 | 11 | 1 | |
| V4 | 2 | 23 | 1 | V2 | 1 | 11 | 3 | |
| V5 | 1 | 11 | 1 | V3 | 1 | 11 | 1 | |
| C-2/29 | WWL1 | 5 | 46 | 1 | WWL1 | 8 | 67 | 1, 2 |
| V2 | 2 | 18 | 1 | V2 | 3 | 25 | 2 | |
| V4 | 3 | 27 | 1 | V6 | 1 | 8 | 1 | |
| V5 | 1 | 9 | 1 | |||||
| C-3/34 | WWL1 | 2 | 18 | 1 | ||||
| V2 | 4 | 36 | 1 | V1 | 2 | 22 | 1 | |
| V4 | 1 | 9 | 1 | V2 | 4 | 44 | 1 | |
| V5 | 3 | 27 | 1 | V5 | 1 | 12 | 1 | |
| V6 | 1 | 9 | 1 | V6 | 2 | 22 | 1 | |
| D-1/84 | WWL2 | 2 | 20 | 1, 2 | WWL2 | 3 | 39 | 1, 3, 4 |
| V1 | 1 | 10 | 1 | V4 | 1 | 12 | 1 | |
| V2 | 2 | 20 | 1 | V5 | 1 | 12 | 1 | |
| V3 | 5 | 50 | 1, 2 | V6 | 1 | 12 | 1 | |
| V7 | 1 | 12 | 1 | |||||
| V8 | 1 | 12 | 1 | |||||
| E-1/3 | V1 | 6 | 55 | 1, 2, 3 | ||||
| V2 | 1 | 9 | 1 | |||||
| V3 | 1 | 9 | 1 | |||||
| V4 | 1 | 9 | 1 | |||||
| V5 | 1 | 9 | 1 | |||||
| V6 | 1 | 9 | 1 | |||||
| E-2/13 | WWL2 | 1 | 10 | 1 | ||||
| V1 | 4 | 40 | 2, 4 | |||||
| V3 | 3 | 30 | 1 | |||||
| V7 | 1 | 10 | 1 | |||||
| V8 | 1 | 10 | 1 | |||||
| E-3/16 | V1 | 6 | 55 | 2 | ||||
| V3 | 1 | 9 | 2 | |||||
| V4 | 1 | 9 | 1 | |||||
| V9 | 1 | 9 | 1 | |||||
| V10 | 1 | 9 | 1 | |||||
| V11 | 1 | 9 | 1 | |||||
| E-4/1 (51)c | V12 | 1 | 6 | 1 | ||||
| V13 | 12 | 75 | 1, 2, 3, 4, 5 | |||||
| V14 | 2 | 13 | 1 | |||||
| V15 | 1 | 6 | 1 | |||||
| F-1/2 | V1 | 5 | 42 | 1 | ||||
| V2 | 1 | 8 | 2 | |||||
| V3 | 1 | 8 | 1 | |||||
| V4 | 5 | 42 | 1 | |||||
The name for each NCRR clone indicates whether it is one of the two archetypes (WWL1 and WWL2) or an mrNCRR clone with major deletions and/or insertions. mrNCRR clones for each individual patient are named V1 to Vn (as shown in Fig. 1), where n is a serial number given to each new unique pattern for that patient only and does not indicate the identity of patterns between patients. The percent column indicates the frequency of each mrNCRR clone among all of the clones derived from the specific clinical sample.
Numbers in this column refer to the names of clones with point mutations (single-nucleotide variants) which were found among the particular archetype or mrNCRR clone shown at the left.
Fifty-one months after the first transplant and 1 month after the second transplant.