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. 2009 Mar 27;191(11):3469–3481. doi: 10.1128/JB.01717-08

TABLE 3.

Colonization of CBA/J mice transurethrally inoculated with wild-type E. coli CFT073 and its genomic island deletion mutants in cochallenge and independent challenge experiments

Genomic islanda Island size (kb) Cochallengeb
Independent challengec
No. of miced P valuese
No. of mice P values
Bladder Kidneys Bladder Kidneys
PAI-CFT073-aspV(PAI III) 100 20 0.0139 <0.0001 11 0.8201 0.3692
φ-CFT073-b0847 33 8 0.2969 0.0781 ND ND ND
PAI-CFT073-serX 113 8 0.6406 0.1563 ND ND ND
φ-CFT073-potB 44 9 0.9102 0.0781 ND ND ND
PAI-CFT073-asnT(HPI) 32 10 0.1641 0.0078 10 0.8793 0.3211
GI-CFT073-asnW 54 13 0.7869 0.5879 13 >0.9999 0.3622
GI-CFT073-cobU 44 10 0.4922 0.4922 ND ND ND
PAI-CFT073-metV 32 16f 0.0020 0.0003 10 0.0668 0.0011
GI-CFT073-selC 68 13 0.2163 0.4648 13 0.6810 0.6139
a

PAI-CFT073-pheV (PAI I) (123 kb) and PAI-CFT073-pheU (PAI II) (52 kb) mutants were not tested in vivo, as these PAIs have already been published.

b

In cochallenge infection experiments, mice were inoculated with a 1:1 ratio of standardized cultures of wild-type CFT073 and a deletion mutant.

c

In independent challenge experiments, mice were inoculated separately with standardized cultures of either wild-type CFT073 or the deletion mutant. ND, not determined.

d

Number of mice with detectable colonization in bladder and/or kidneys.

e

P values comparing the ability of the mutants with the indicated genomic island to colonize the bladder and kidneys of mice shown in bold type were statistically significant (P < 0.05). P values for cochallenge infections were determined using the Wilcoxon matched-pair test. P values for independent challenges were determined using the Mann-Whitney test.

f

Sixteen mice were used in the PAI-metV cochallenge experiments, although only 14 data points were usable for the bladder data.