TABLE 1.

Percentage of CD4⁺ or CD8⁺ T cells in H-2^d mice following weekly administration of anti-mouse CD4 (GK1.5) or CD8 (2.43) monoclonal antibody^a

Time point	% T cells in indicated subset with or without antibody treatment
	CD4+		CD8+
	No treatment	Anti-CD4	No treatment	Anti-CD8
wk 1	15.1	0.2	12.9	0.1
wk 2	13.5	0.1	11.0	0.1
wk 3	23.5	0.2	13.3	0.1
wk 4	23.6	0.1	16.6	0.2

^aValues represent a percentage of the total number of splenocytes that were counted, are an average for two animals per group, and were detected with monoclonal antibodies distinct from those used for the depletion; CD4⁺ T cells were labeled with antibody L3T4, and CD8⁺ T cells were labeled with antibody Ly-3.2. Levels of CD4⁺ T cells were not affected by the administration of anti-CD8 antibody and vice versa (not shown).