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. 2009 Mar 18;83(11):5514–5524. doi: 10.1128/JVI.00145-09

FIG. 7.

FIG. 7.

Anti-SIV efficacy in vitro of CD8+ cells. PBMC-derived CD8 (target) cells infected with SIVmac239 were cultured alone (no CD8) or cocultured with autologous PBMC-derived CD8+ (effector) cells obtained prechallenge (pre) or at week 3 postchallenge (wk 3) at an E/T ratio of 1:4. The results were obtained from three unimmunized controls and four NAb-immunized macaques. The ratios of p27 concentrations in the culture supernatants after 8 days of coculture with pre-CD8+ or week 3 CD8+ cells to those without CD8+ cells (CD8 negative) are shown. The coculture with either R03-011 week 3 CD8+, R03-020 week 3 CD8+, and R03-013 week 3 CD8+ cells showed undetectable or marginal SIV p27 production after 8 days.