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. 2009 Mar 18;83(11):5514–5524. doi: 10.1128/JVI.00145-09

FIG. 8.

FIG. 8.

Gag-specific CD8+ T-cell responses in the chronic phase. PBMCs around week 30 postchallenge were stimulated with p55, and specific induction of IFN-γ, TNF-α, IL-2, MIP-1β, and CD107a in CD8+ T cells was examined. (A) Frequencies of total Gag-specific CD8+ T cells. (B) Percentages of cells exhibiting Gag-specific induction of single or multiple marker cytokines in total Gag-specific CD8+ T cells. See the legend to Fig. 2 for symbols. (C) Frequencies of Gag-specific CD8+ T cells exhibiting Gag-specific induction of ≥3 marker cytokines (polyfunctional; left) or ≥4 marker cytokines (highly polyfunctional; right) in total CD8+ T cells. The highly polyfunctional Gag-specific CD8+ T-cell frequencies in NAb-immunized macaques were significantly higher than in unimmunized controls (P = 0.023).