TABLE 1.

Agonists, kinases, and Sp1 phosphorylation^a

Protein	Cell type	Stimulus	Kinase(s)	DNA bindingb	Transcriptional changeb	Reference
PDGFR-α	SMCs	FGF-2	ERK	↑	↓	3
PDGF-B	SMCs	NOG	PKC-ζ	↑	↑	52
PDGF-D	SMCs	Ang II	PKC-ζ	↑	↑	63
FasL	SMCs	CAM	PKC-ζ	↑	↑	30
MMP1	Rat endothelial cells	Shear stress	PKC-ζ	↑	↓	33
Nitric oxide synthase	HUVEC	Lysophosphatidylcholine	PP2A	↑	↑	13
VEGF	Fibroblasts	Neu differentiation factor	p42/p44 MAPK	↑	↑	46
Tyrosine kinase	Fibroblasts	Cyclin A	CDK-2	↑	↑	18
DHFR	Fibroblasts	Cyclin A	CDK-2	↑	↑	17
Gastrin	Gastric carcinoma cells	EGF	ERK2	↑	↑	12
VEGF	Keratinocytes	HGF	PI3K, MEK1/2, PKC-ζ		↑	54
Cyclin D3	Megakaryocytes	Thrombopoietin	PP1	↓	↓	67
HIV-1 LTR	T lymphocytes	CD2/CD28	PP2A	↓	↓	35
Aldolase	Hepatoma cells	Glucose	PP1	↓	↓	58
Pyruvate kinase	Hepatoma cells	Glucose	PP1	↓	↓	58
Acetyl-coenzyme A carboxylase	Proadipocytes	Glucose	PP1	↓	↓	14
MMP2	Human lung cancer	NSAID	ERK	↑	↑	50
α-ENaC2	Lung epithelial cells	Thrombopoietin	PP1	↑	↑	9
LHR	Choriocarcinoma and breast cancer cells	TSA	PKC-ζ	↑	↑	69
HO-1	Human embryonic kidney	NGF	PI3K, PKC-ζ, MEK, ERK	↑	↑	55

^aAbbreviations: CAM, calmodulin; NSAID, nonsteroidal anti-inflammatory drug; NOG, nogalamycin; NGF, nerve growth factor; LTR, long terminal repeat; HUVEC, human umbilical vein endothelial cells; DHFR, dihydrofolate reductase; α-ENaC2, α Na⁺ channel 2; MMP1, matrix metalloproteinase 1; HGF, hepatocyte growth factor.

^b↑, increase; ↓, decrease.