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. 2009 Mar 16;29(10):2594–2608. doi: 10.1128/MCB.01396-08

FIG. 1.

FIG. 1.

In silico analysis of the BECN1 promoter. (A, top) genomic organization of the human (ENSG00000126581) and mouse (ENSMUSG00000035086) BECN1 genes according to Ensembl. (A, bottom) Exact position (as shown by asterisks) of the κB site predicted in the human and mouse BECN1 promoters by CONFAC analysis. (B) Mann-Whitney test results. CONFAC consolidated conserved transcription factor binding sites for the list of NF-κB target (targ) genes, including BECN1, and for a control list of 100 randomly selected control genes were compared. Statistical analysis parameters are shown on the right. (C) Exact positions (as shown by asterisks) of the κB sites located in a DNA segment containing 1.1 kbp (CHET4) of the human BECN1 promoter, according to TRANSFAC Professional. The κB site confirmed both by CONFAC and TRANSFAC is in white. (Top) Genomic organization of BECN1 with respect to the CHET4 sequence (boxed). UTR, untranslated region; Std, standard; Dev, deviation; Err, error; Cons., consolidated.