TABLE 1.
Mice of various genotypes generated by Cdk2+/− p53−/− intercrossing
Genotype | No. of micea | % of mice
|
|
---|---|---|---|
Observed | Expected | ||
Cdk2+/+p53+/+ | 75 | 6.5 | 6.25 |
Cdk2+/+p53+/− | 163 | 14.2 | 12.5 |
Cdk2+/+p53−/− | 51 | 4.4 | 6.25 |
Cdk2+/−p53+/+ | 165 | 14.4 | 12.5 |
Cdk2+/−p53+/− | 328 | 28.5 | 25 |
Cdk2+/−p53−/− | 91 | 7.9 | 12.5 |
Cdk2−/−p53+/+ | 92 | 8.0 | 6.25 |
Cdk2−/−p53+/− | 143 | 12.4 | 12.5 |
Cdk2−/−p53−/− | 41* | 3.6 | 6.25 |
Total | 1,149 |
*, significant difference from the expected Mendelian ratio.