TABLE 1.
BGLF4 and CDK1 substratesa
| EBV ORF | BGLF4 | CDK1/cyclin B |
|---|---|---|
| Latency genes | ||
| BNLF1 (LMP1 exon 3) | + | − |
| BYRF1 (EBNA2) | + | + |
| A73 (BART ORF) | + | + |
| BKRF1 (EBNA1 aa 386-641) | + | + |
| LMP2A | − | + |
| Lytic genes | ||
| BGLF5 (alkaline exonuclease) | + | + |
| BXLF1 (TK) | + | + |
| BALF2 (single-stranded DNA binding protein) | + | − |
| BBLF4 (helicase) | + | − |
| BBRF3 (glycoprotein M) | + | + |
| BLLF1 (gp350) | + | − |
| BALF1 (antiapoptotic) | + | − |
| BILF1 (G-protein-coupled receptor) | + | + |
| BORF1 (capsid) | + | − |
| BORF2 (ribonucleotide reductase, large subunit) | + | − |
| BGLF2 (capsid maturation) | + | − |
| BKRF3 (uracil DNA glycosylase) | + | + |
| BDLF1 (capsid) | + | + |
| BMLF1 (MTA, post-transcriptional regulator) | + | − |
| BMRF1 (polymerase processivity factor) | + | − |
| BLRF1 (glycoprotein N) | + | − |
| BaRF1 (ribonucleotide reductase, small subunit) | − | + |
| BDRF1 (terminase exon 2) | + | + |
a
+, phosphorylated; −, not phosphorylated; BART, BamHI-A rightward transcript.