FIG. 9.

Results of an animal experiment in which pigs were infected with the RNase-negative CSFV V-H297K (group 1, 3 pigs), the dimerization-negative point mutant V-C171S (group 2, 4 pigs) or wt Alfort/Tübingen recovered from the infectious cDNA clone (group 3, 3 pigs). (A to C) Mean values of clinical scores (A), body temperature (B), and leukocyte numbers (C) for each group of animals. (D) Titers of virus-neutralizing serum antibodies of the pigs are given as the maximal reciprocal dilution of the sera that are able to neutralize 65 TCID₅₀ of CSFV Alfort/Tübingen. Standard deviations are indicated in panel A.