TABLE 3.
Cross-protection results after single-dose immunizations and challenge with different H5N1 strains
| Immunizationa | Protection [no. of survivors/total (%)] against challenge withb:
|
||
|---|---|---|---|
| VN1203 | HK156 | IN5/05 | |
| Inact. whvv | 6/6 (100) | 6/6 (100) | 6/6 (100) |
| dVV-HA5 | 6/6 (100) | 6/6 (100) | 6/6 (100) |
| rVV-HA5 | 6/6 (100) | 6/6 (100) | 6/6 (100) |
| rVV-HA-VN | 6/6 (100) | 6/6 (100) | 6/6 (100) |
| VV-Lister | 0/6 (0) | 0/6 (0) | 0/6 (0) |
| PBS | 0/6 (0) | 0/6 (0) | 0/6 (0) |
a
See Table 1 for vaccine abbreviations.
b
Challenge dose, 1 × 105 TCID50; the LD50s for BALB/c mice for the HK156, VN1203, and IN5/05 strains were 11, 24, and 18 TCID50, respectively. Protection of mice was highly significant in the groups immunized with HA-containing vaccines compared to that for the controls (P < 0.001).