Annexin A2 is a component of the primary enveloped virion. (A) Three fractions, TCE, NMP, and pnHSV-1, were subjected to Western blotting and probed with antibodies against VP5 and annexin A2. (B) The pnHSV-1 preparation was subjected to immunogold EM labeling for annexin A2. The images show two examples of annexin A2 labeling within the primary enveloped virion. Bars, 200 nm.