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. 2009 Mar 11;83(10):5256–5268. doi: 10.1128/JVI.01997-08

FIG. 2.

FIG. 2.

Analysis of expression of activation markers on HSV-1 gB-specific CD8+ T cells in CD4-depleted, B6-MHC-II−/−, and WT mice in response to acute infection with HSV-1. Draining PLN cells were obtained from WT, CD4-depleted, or B6-MHC-II−/− mice 5 days following infection of each hind FP with HSV-1 and stained using anti-CD8α, anti-CD44, anti-CD25, and H-2Kb-gB tetramers. (A and B) Expression of CD44 on HSV-1 gB-specific CD8+ T cells in WT compared to CD4-depleted B6 mice (A) and WT compared to B6-MHC-II−/− mice (B). (C and D) Expression of CD25 in WT compared to CD4-depleted B6 mice (C) and WT compared to B6-MHC-II−/− mice (D). Solid lines, WT; dotted lines, CD4-depleted or B6-MHC-II−/− mice. Data are representative of two independent experiments for each group.