FIG. 6.

Kinetic analysis of in vivo cytolytic activity in WT and CD4-depleted mice. WT, CD4-depleted, and B6-MHC-II^−/− mice were infected in each hind FP with 2 × 10⁶ PFU HSV-1 and examined for HSV-1-specific cytolytic function in vivo using a CFSE-based assay as described in Materials and Methods. The presence of CFSE^hi and CFSE^lo cells remaining 1, 2, and 4 h after i.v. transfer of target cells was determined. No significant difference was apparent between the two experimental groups at any time point examined.