FIG. 7.

CD4 depletion does not affect CTL activity in vivo. (A) Representative histograms from the PLN of naïve, CD4-depleted, and nondepleted B6 mice, 5 days post-HSV-1 infection. (B) Percent specific lysis as a function of peptide concentration (means ± SEM). Percent specific lysis was calculated as described in the text. Squares, naïve mice; triangles, CD4-depleted mice; circles, nondepleted mice. Statistical analysis using the Wilcoxon sum of ranks test revealed no significant differences in the percentage of HSV-1-specific lysis between CD4-depleted and nondepleted mice at any of the concentrations examined.