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Mean 6 min walk distance (6MWD) before and after combination therapy. *P<0.02. BL1 Baseline 1 (before bosentan initiation); BL2 Baseline 2 (before initiation of bosentan plus silden-afil therapy); 3M Three months postinitiation of bosentan treatment; 3M2 Three months postinitiation of bosentan plus sildenafil treatment; 6M Six months postinitiation of bosentan treatment; 6M2 Six months postinitiation of bosentan plus sildenafil treatment
