Table 5.
Genotype distribution of genes encoding enzymes involved in metabolism and biosynthesis in adolescent girls with polycystic ovary syndrome and healthy controls
| Gene | Genotype | Cases (n = 44) | Controls (n = 50) | P | OR (95% CIs);P |
|---|---|---|---|---|---|
| CYP17 | -34 T/C (rs743572) | 0.383 | |||
| TT | 15 (34%) | 20 (40%) | 1a | ||
| TC | 19 (43%) | 24 (48%) | 1.06 (0.43-2.60); 0.906 | ||
| CC | 10 (23%) | 6 (12%) | 2.22 (0.66-7.48); 0.193 | ||
| TC + CC | 29 (66%) | 30 (60%) | 1.29 (0.56-2.99); 0.554 | ||
| Allele frequency | 0.245 | ||||
| T | 49 (55.7%) | 64 (64%) | 1a | ||
| C | 39 (44.3%) | 36 (36%) | 1.42 (0.79-2.54); 0.245 | ||
| CYP1A1 | T6235C (rs4646903) | 0.188 | |||
| TT | 26 (59%) | 36 (72%) | 1a | ||
| CT | 18 (41%) | 14 (28%) | 1.78 (0.75-4.21); 0.188 | ||
| CC | 0 (0%) | 0 (0%) | NC | ||
| Allele frequency | 0.240 | ||||
| T | 70 (79.54%) | 86 (86%) | 1a | ||
| C | 18 (20.45%) | 14 (14%) | 1.58 (0.73-3.40); 0.240 |
OR, odds ratio; CIs, confidence intervals.
aReference genotype/allele.
NC, Not Calculated