Table 1.
Targets and selected drugs for melanoma therapy
| Main targets | Inhibitors | Other known targets |
|---|---|---|
| c-Kit | Imatinib | Bcr-Abl, PDGFRα/β |
| SU11248(sunitinib) | VEGFR, PDGFRα/β | |
| c-Met | SU11274 | Unknown |
| PHA-665752 | Unknown | |
| Ras | Tipifarnib (Zanestra) | Farnesylated proteins |
| SCH66336 | Farnesylated proteins | |
| Raf | Sorafenib (BAY-439006) | VEGFR2, PDGFRβ |
| CHIR-265 | VEGFR, PDGFRα/β | |
| PLX720 | Unknown | |
| MEK | CI-1040 (PD184352) | Unknown |
| ARRY-142886 (AZD6244) | Unknown | |
| PD0325901 | Unknown | |
| Lethal Factor (LF) | Unknown | |
| mTOR | Rapamycin | Unknown |
| CCI779 (temsirolimus) | Unknown | |
| RAD-001 (everolimus) | Unknown | |
| AP-23573 (deforolimus) | Unknown | |