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. 2009 May 29;5(5):e1000460. doi: 10.1371/journal.ppat.1000460

Figure 4. In Vivo growth of Δrv2623 in mice.

Figure 4

(A) C57BL/6 mice infected with various strains of M. tuberculosis via the aerosol route with a low dose (∼100 CFU) were assessed for lung bacteria burden. Wild type Erdman (closed box, solid line); Δrv2623 (open box, dashed line) and the complemented strain Δrv2623 Phsp60::Rv2623 (triangle, dashed line). (B) Survival curve of C3H/HeJ mice infected via aerosol with 750–1000 CFU. Erdman and Δrv2623-infected mice are represented by solid and dashed lines, respectively. (C) Kinetics of infection, established via aerolization (inoculum: ∼1,000 CFU) of wildtype Erdman (dark), Δrv2623 (dark grey), and the complemented strain Δrv2623 Phsp60::Rv2623 (light grey), as assessed by lung bacterial burden. **p<0.01; ***p<0.001.