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. 2009 May 29;5(5):e1000460. doi: 10.1371/journal.ppat.1000460

Figure 8. ATP binding by Rv2623 is required for its ability to attenuate growth.

Figure 8

Growth of M. smegmatis (A) or M. tuberculosis (B) overexpressing wild type or mutant Rv2623 inoculated at 104, 105 CFU/ml into a BD BACTEC 9000MB system; the time to detection of triplicate cultures is indicated. While overexpression of wildtype Rv2623 attenuates mycobacterial growth, overexpression of either ATP-binding-deficient Rv2623 mutant (Rv2623G117A or Rv2623D15E) significantly shifts the time to detection back towards that of the pMV261 vector control strain. ***p<0.001.