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. 2009 May 29;5(5):e1000394. doi: 10.1371/journal.pcbi.1000394

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Pries et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — Top row: results obtained with measured vessel diameters. Middle and bottom rows: simulated ‘normal adaptation’ and ‘tumor adaptation’. The tumor network with measured diameters and either network subjected to ‘tumor adaptation’ (right column) exhibit high structural heterogeneity and uneven flow distribution in comparison to the mesentery network and either network subjected to ‘normal adaptation’ (left column). For the adapted networks, results of individual randomized runs are shown. Values of oxygen deficit (O_2def) and diameter mismatch (d³ _var) were similar to the mean values reported in Figure 3. For the sake of a better representation of individual vessel segments, only parts of the simulated networks are shown. The mesentery network comprised a total of 546 vessels supplying an area of about 4×7 mm, whereas the tumor vascular network comprised a total of 290 vessels in an area of about 1×0.8 mm.

Top row: results obtained with measured vessel diameters. Middle and bottom rows: simulated ‘normal adaptation’ and ‘tumor adaptation’. The tumor network with measured diameters and either network subjected to ‘tumor adaptation’ (right column) exhibit high structural heterogeneity and uneven flow distribution in comparison to the mesentery network and either network subjected to ‘normal adaptation’ (left column). For the adapted networks, results of individual randomized runs are shown. Values of oxygen deficit (O_2def) and diameter mismatch (d³ _var) were similar to the mean values reported in Figure 3. For the sake of a better representation of individual vessel segments, only parts of the simulated networks are shown. The mesentery network comprised a total of 546 vessels supplying an area of about 4×7 mm, whereas the tumor vascular network comprised a total of 290 vessels in an area of about 1×0.8 mm.