Table 5a.

Multivariable adjusted^* hazard ratios (HRs) and 95% confidence intervals (CIs) for haplotypes >1% in the ADRB2 gene (considering the Gly16Arg, Gln27Glu, and Thr164Ile polymorphisms) among Caucasian women with ischemic vascular events in the Women's Health Study (n=23,805^†): Gly16-Glu27-Thr164 as the reference haplotype

Haplotypes	HR	95% CI	p-value
Myocardial infarction (n=253)
Gly16-Glu27-Thr164	Reference	------	----
Gly16-Gln27-Thr164	0.75	0.58−0.97	0.03
Gly16-Gln27-Ile164	0.95	0.45−1.98	0.88
Arg16-Gln27-Thr164	0.98	0.81−1.19	0.85
Ischemic stroke (n=275)
Gly16-Glu27-Thr164	Reference	------	----
Gly16-Gln27-Thr164	1.20	0.96−1.51	0.11
Gly16-Gln27-Ile164	1.21	0.63−2.31	0.57
Arg16-Gln27-Thr164	1.14	0.94−1.38	0.20
Death due to cardiovascular disease (n=150)
Gly16-Glu27-Thr164	Reference	-----	----
Gly16-Gln27-Thr164	1.02	0.75−1.39	0.89
Gly16-Gln27-Ile164	1.15	0.48−2.74	0.76
Arg16-Gln27-Thr164	0.92	0.71−1.20	0.54

^*adjusting for: age, body mass index, history of hypertension, diabetes, physical activity, smoking categories, alcohol consumption, postmenopausal hormone use, oral contraceptive use, family history of myocardial infarction before age 60, and randomizedaspirin assignment.

^†9 women were deleted from the analysis with a posterior probability ≤ 95% of the inferred haplotypes.