Table 2.
Source | Gene | Definition | Function | No. of Subjects |
Results [ref.] |
---|---|---|---|---|---|
Elkins | dsrA | ducreyi serum resistance A |
OMP; major role in serum resistance |
6 | Attenuated [46] |
Kawula | ncaA | necessary for collagen adherence |
OMP; confers collagen binding |
10 | Attenuated [26] |
Hansen |
lspA1 lspA2 |
double mutant, large supernatant proteins |
secreted proteins; prevent Fc-g mediated phagocytosis |
6 | Attenuated [24] |
Spinola | pal | peptidoglycan associated lipoprotein |
lipoprotein; OM stability | 9 | Attenuated [47] |
Hansen | tadA | tight adherence protein A | type IV secretion; secretion of Flp proteins |
15 | Attenuated [23] |
Bauer Janowicz |
fgbA | putative fibrinogen binding adhesin |
OMP that binds to fibrinogen in ligand blot |
6 | Partially Attenuated [30] |
Elkins | dltA | ducreyi lectin A | OMP; partial serum resistance |
7 | Partially Attenuated [25] |
Munson | hhdB | secretion/activation of hemolysin |
lyses fibroblasts | 6 | Virulent [32] |
Munson | losB | D-glycero-D-manno- heptosyltransferase |
extends LOS beyond KDO-triheptose-glucose |
5 | Virulent [31] |
Munson | lst | lipooligosaccharide sialyltransferase |
adds sialic acid to major glycoform of LOS |
5 | Virulent [31] |
Campagnari Munson |
glu | glucosyltransferase gene | adds glucose to KDO- triheptose LOS core |
5 | Virulent [48] |
Hansen | cdtC | cytolethal distending toxin | toxic for T cells, epithelial cells, fibroblasts |
6 | Virulent [33] |
Hansen Munson | cdtC hhdB | double mutant, cytolethal distending toxin, hemolysin |
see above | 5 | Virulent [33] |
Kawula | sodC | superoxide dismutase C | detoxifies ROS for bacteria in phagolysosomes |
6 | Virulent [34] |
Spinola Hansen |
momp | major outer membrane protein |
OmpA homologue; minor role in fibronectin binding |
6 | Virulent [49] |
Campagnari |
ompP2A ompP2B |
double mutant, porin proteins |
encode known classical trimeric porins |
8 | Virulent [27] |
Spinola | ftpA | fine tangled pilus major subunit |
unknown | 7 | Virulent [50] |
Elkins | hgbA | hemoglobin binding outer membrane protein |
heme/iron acquisition and transport from hemoglobin |
9 | Attenuated [35] |
Elkins | tdX/tdhA | double mutant; ton B dependent receptors |
heme uptake | 6 | Virulent [28] |
Munson | wecA | first enzyme in the ECA biosynthetic pathway |
initiates synthesis of putative ECA glycoconjugate |
5 | Partially Attenuated [29] |