Effects of TAT2 on proliferative capacity and telomere length in T cells. a, Population doublings of CD8+ T cells from a representative HIV+ donor treated with either TAT2 (1 μM) or DMSO (0.1%) every 48–96 h. Symbols indicate stimulation of cells with CD2/3/28 Ab-coated beads, done every 13–17 days. Immediately before addition of beads, cells were counted and total population doublings were calculated. b, Relative telomere length of CD8+ T cells from HIV+ donor treated with TAT2 or DMSO. Symbols indicate time points at which cells were harvested for telomere length assessment. Telomere length data are reported as % telomere length of the acute lymphoblastic T cell line, 1301.