Table 4.
Change in gene expression in the NF-κB signalling pathway.
| WKY | SHR | SHR-Ang-(1−7) | Diabetic SHR | Diabetic SHR+Ang-(1−7) | Diabetic SHR+captopril | |
|---|---|---|---|---|---|---|
| Activation of the NF-κB pathway | ||||||
| NM_198769 Tlr2 | 1 | 1.52 | 0.99 | 1.52 | 0.88 | 0.83 |
| NM_053355 Ikbkb/AIM-1 | 1 | 1.58 | 0.87 | 1.92 | 0.66 | 0.64 |
| XM_343844 Irak1 | 1 | 2.01 | 1.03 | 2.35 | 0.69 | 0.77 |
| Inflammatory response genes | ||||||
| NM_016994 C3 | 1 | 2.45 | 0.70 | 2.85 | 0.66 | 0.63 |
| NM_031512 Il-1β | 1 | 1.85 | 1.21 | 2.68 | 0.54 | 0.64 |
| NM_012589 Il-6 | 1 | 1.30 | 0.92 | 2.58 | 0.52 | 0.61 |
| XM_218181 Nalp12 | 1 | 2.60 | 1.40 | 2.09 | 0.26 | 0.33 |
| NM_012762 Casp1 | 1 | 2.45 | 0.90 | 3.16 | 0.55 | 0.68 |
Reactions were run in duplicates using an RNA sample pooled from three rats. Changes in gene expression were calculated based on the 2-ΔCt method. All the values indicate the increase (above 1) or decrease (below 1) compared to WKY.