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. Author manuscript; available in PMC: 2009 Sep 30.
Published in final edited form as: J Neuroimmunol. 2009 Feb 4;208(1-2):119–124. doi: 10.1016/j.jneuroim.2009.01.003

Table 2.

Previous studied on the role of chromosome 19q13 in MS susceptibility

Reference Type of study Best marker/subregion Country Subjects Significance
Sawcer et al. (1996) Linkage d19s246/19q13.4 UK 227 multiplex families LOD=1
Haines et al. (1996) Linkage d19s219/19q13.2 USA 52 multiplex families LOD=1.13
Ebers et al. (1996) Linkage d19s47/19q13.2 Canada 100 sibling pairs LOD=0.73
Kuokkanen et al. (1997) Linkage d19s246/19q13.4 Finland 16 multiples families LOD=1
D’Alfonso et al. (1999) Linkage 19q13.3 Italy 69 families LOD<0.7
Coraddu et al. (2001) Linkage 19q13 Italy/Sardinia 49 multiplex families LOD<0.7
Broadley et al. (2001) Linkage 19q13 Italy 40 multiplex families LOD<0.7
Green et al. (2001) Linkage CEA/19q13.2 USA 161 multiplex LOD=1.25
Xu et al. (2001) Linkage D19S246/19q13.4 Sweden 46 multiplex families NPL score -0.46
Reunanen et al. (2002) Linkage d19s876/19q13.1 Finland 27 multiplex families LOD=1.8
Haines et al. (2002) Linkage d19s879/19q13.4 USA 98 multiplex families LOD=3.01
Lucotte et al. (2002) Linkage 19q13.3 France 18 multiplex families LOD=2.1
Pericak-Vance et al. (2004) Linkage D19S217/19q13.2 USA 98 multiplex families LOD=2.17
Pericak-Vance et al. (2004) Linkage D19S217/19q13.2 USA 53 families, HLA-DR15+ LOD=2.37
Pericak-Vance et al. (2004) Linkage D19S217/19q13.2 France 90 families LOD<0.7
Haghighi et al. (2006) Linkage with OCBa D2S219/19q13.2 Sweden 2 extended families LOD=1.8
Schmidt et al. (2002) Association APOE ε2-haplotype USA 328 families p=0.005
Yeo et al. (2003) Association d19s585/19q13.4 UK 961 patients p=0.12
Ban et al. (2003) Association d19s219/19q13.2 Australia 217 patients p=0.009
Koch et al. (2005) Association ILT6/19q13.4 Germany, France 751 patients p=0.009
Burwick et al. (2006) Association APOE/19q13.2 Meta-analysis 3200 patients p>0.05
Burton et al. (2007) Association ZNF45 and GIPR/19q13.2 UK 1000 patients p=0.00005 and p=0.0008
Hafler et al. (2007) Associationb MAG, CD22, TYROBP/19q13.1c UK, USA 931 trios/2431 controls p>0.05
Hafler et al. (2007) Associationb APOE, ZNF45, GIPR/19q13.2c UK, USA 931 trios/2431 controls p>0.05
Hafler et al. (2007) Associationb synaptogyrin4/13q13.3d UK, USA 931 trios/2431 controls p=0.02/0.0003
Hafler et al. (2007) Associationb ZNF577/19q13.4d UK, USA 931 trios/2431 controls p=0.04/0.001
a

OCB = oligoclonal bands in cerebrospinal fluid.

b

We search for association on chromosome 19q13 between positions 40 Mb and 60 Mb for the following criteria: TDT statistics have a p-value<0.05 or CMH statistics have a p-value<0.001 (https://imsgc.org/php/results.php).

c

The 19q13.1 region harbouring MAG, CD22, TYROBP (40-42 Mb) and the 19q13.2 region harbouring APOE, ZNF45 and GIPR (49-51 Mb) were analysed with 128 and 177 markers, respectively, all of which failed to show any association (in both TDT and CMH statistics).

d

These markers fulfilled the association criteria.