Nicotine dose-dependently increased the Vmax of
[3H]DA uptake in the prefrontal cortex, but not in the striatum.
Nicotine (0, 0.3, and 0.8 mg/kg s.c.) was administered, and brain regions were
obtained 30 min later. Data from two independent control groups administered
saline contemporaneously with each nicotine dose were pooled for graphical
presentation. Kinetic analysis of synaptosomal [3H]DA uptake was
determined in the presence of desipramine (1 μM) and paroxetine (5 nM).
Vmax values (picomoles per milligram per minute) in the
prefrontal cortex (A) and striatum (B) are expressed as mean ± S.E.M.
Both brain regions were obtained from each subject (n = 7
rats/treatment group). *, p < 0.05 different from
saline-control group.