Fig. 1.

Nicotine dose-dependently increased the V_max of [³H]DA uptake in the prefrontal cortex, but not in the striatum. Nicotine (0, 0.3, and 0.8 mg/kg s.c.) was administered, and brain regions were obtained 30 min later. Data from two independent control groups administered saline contemporaneously with each nicotine dose were pooled for graphical presentation. Kinetic analysis of synaptosomal [³H]DA uptake was determined in the presence of desipramine (1 μM) and paroxetine (5 nM). V_max values (picomoles per milligram per minute) in the prefrontal cortex (A) and striatum (B) are expressed as mean ± S.E.M. Both brain regions were obtained from each subject (n = 7 rats/treatment group). ^*, p < 0.05 different from saline-control group.