TABLE 2.

In vivo antagonism potencies and in vitro receptor binding affinities of MDL100907

	MDL100907	Ketanserin	Ritanserin
In vivo antagonism
DOM discriminative stimulus (pA2, mg/kg)	0.0006a (0.0003-0.0012)	0.0075a (0.0053-0.0157)	0.0102a (0.0071-0.0158)
(±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane -induced head twitch (ED50, mg/kg)	0.005b	0.029c (0.009-0.096)	0.027c (0.008-0.091)
In vitro binding
5-HT2A receptor (Ki, nM)	0.85d	3.16c	3.80c
5-HT2C receptor (Ki, nM)	88d	186c	2.3c
α1 Adrenergic (Ki, nM)	128d	15c	190c

^aPotency (milligrams per kilogram) to antagonize the DOM discriminative stimulus in monkeys (values in parentheses are the 95% confidence limits).

^bED₅₀ recalculated from Vickers et al. (2001).

^cFrom Kleven et al. (1997) (values in parentheses are 95% confidence limits).

^dFrom Kehne et al. (1996).