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Increased novelty-induced locomotor activity in KO mice compared with WT mice. WT and KO mice (n = 6) were placed in a novel environment, and locomotor activity was recorded over 2 h. A two-way ANOVA (genotype × time) revealed a significant main effect of genotype [F(1,207) = 20.27, p < 0.01]. KO mice showed significantly higher locomotor activity than WT mice. Data are represented as mean ± S.E.M.
