Fig. 1.

Cannabidiol dose-dependently attenuates the cisplatin-induced renal dysfunction. CP induced profound renal dysfunction 72 h after the administration to mice evidenced by increased serum levels of BUN and creatinine, which were dose-dependently attenuated by CBD treatment. CBD (10 mg/kg/day i.p.), even given 12 h after the CP exposure, was able to attenuate the renal dysfunction. Results are mean ± S.E.M. of six experiments in each group. ^*, P < 0.05 versus vehicle; †, P < 0.05 versus cisplatin.