Fig. 2.

Cannabidiol attenuates the cisplatin-induced renal dysfunction and histopathological damage. Cisplatin induced profound renal dysfunction and injury 72 h after the administration to mice evidenced by increased serum levels of BUN and creatinine (A) and histopathological damage evaluated by PAS staining (B), which were attenuated by CBD treatment (10 mg/kg/day i.p. starting from 1.5 h before CP exposure). Results are mean ± S.E.M. of five to six experiments in each group. ^*, P < 0.05 versus vehicle; †, P < 0.05 versus cisplatin.