Fig. 5.

Cannabidiol attenuates the cisplatin-induced renal overexpression of superoxide generating enzymes NOX4 (RENOX) and NOX1 (A and B) and MDA formation. Cisplatin induced marked increases in mRNA expression of NOX4 and NOX1 (A and B) and increased lipid peroxidation (C) in the kidneys 72 h after the administration to mice, which were attenuated by CBD (10 mg/kg/day i.p. starting from 1.5 h before CP exposure) treatment. Results are mean ± S.E.M. of five to six experiments in each group. ^*, P < 0.05 versus vehicle; †, P < 0.05 versus cisplatin.