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Nalmefene reversal of ongoing salvinorin A-induced facial relaxation (top) and ptosis (bottom) (n = 5). Nalmefene (0.1 mg/kg i.v.) or vehicle were administered 11 min after salvinorin A (0.032 mg/kg). Therefore, observations after this nalmefene or vehicle treatment are used to evaluate the effectiveness of reversal. Note modified time windows to focus on postreversal period. Other details as in Fig. 4.
