Fig. 7.

Actions of Panx1 inhibitors on ATP-evoked currents in cells coexpressing Panx1 and P2X₇ receptor. A, examples of ATP-evoked currents in the presence and absence of CBX, NPPB, and MFQ as indicated; currents were slightly increased or unaltered. B, example of ATP-evoked currents in the absence and presence of DIDS. C, summary of all experiments as illustrated in A and B; results for NPPB and MFQ at each of the three P2X₇Rs are pooled because there was minimal or no effect, whereas inhibition by DIDS is shown for each species, n = 5 to 18 for each point. DIDS IC₅₀ values were 90 ± 4, 130 ± 12, and 195 ± 21 μM for rat, mouse, and human P2X₇R, respectively.