TABLE 2.
Recombinant Rat α3β4 nAChRsa ([Ca2+]i) EC50 or IC50 | Native Bovine α3β4* nAChRs (Neurosecretion) EC50 or IC50 | |
---|---|---|
μM | ||
Nicotine | 18.0 (15.9–20.4) | 3.6 (2.9–4.5)b |
Epibatidine | 0.06 (0.05–0.07) | 0.009 (0.006–0.014)b |
d-Tubocurarine | 6.3 (5.0–8.1) | 2.2 (1.4–3.6)c |
Mecamylamine | 0.6 (0.4–0.8) | 0.1 (0.1–0.7)d |
Tetracaine | 2.5 (2.4–2.6) | 4.0 (2.2–7.4)d |
COB-2 | 1.1 (1.0–1.1)e | 1.2 (1.2–1.3)e |