Figure 3. IL-2 complex administration is not effective at reducing viral loads in the absence of perforin, but is effective when IFN-γ is blocked.
(A) Wild-type and perforin deficient mice were depleted of CD4 T cells and treated with IL-2 complex as in Figure 1A. (B) An IFN-γ blocking antibody was given at the same time as IL-2 complex administration. Viral loads were determined via the standard plaque assay.