Table 1.
Baseline Patient Characteristics
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |||
|---|---|---|---|---|---|---|
| Characteristics | Overall (n=486) | TNFα<1.5 pg/mL (n=118) | 1.5 TNFα<2.1 pg/mL (n=130) | 2.1 TNFα<3.1 pg/mL (n=120) | TNFα 3.1 pg/mL (n=118) | Ptrend |
| Age (yrs), mean (SD) | 76.7 (13.0) | 74.4 (12.5) | 77.0 (14.0) | 78.2 (11.8) | 77.1 (13.2) | 0.09 |
| Male | 236 (48.6) | 52 (44.1) | 65 (50.0) | 64 (53.3) | 55 (46.6) | 0.60 |
| EF | 49.2 (16.4) | 47.9 (17.4) | 47.7 (16.4) | 50.3 (16.2) | 51.1 (15.6) | 0.07 |
| EF≥50% | 266 (54.8) | 61 (51.7) | 66 (50.8) | 69 (58.0) | 70 (59.3) | 0.14 |
| Risk Factors | ||||||
| Hypertension | 391 (80.4) | 86 (72.9) | 109 (83.8) | 98 (81.7) | 98 (83.1) | 0.09 |
| Current smoker | 40 (8.2) | 20 (17.1) | 5 (3.8) | 10 (8.3) | 5 (4.2) | 0.003 |
| Hyperlipidemia | 326 (67.1) | 78 (66.1) | 89 (68.5) | 79 (65.8) | 80 (67.8) | 0.91 |
| Diabetes | 148 (30.5) | 30 (25.4) | 42 (32.3) | 42 (35.0) | 34 (28.8) | 0.50 |
| BMI (kg/m2), mean (SD) | 29.2 (7.9) | 29.5 (8.3) | 29.3 (7.9) | 28.8 (7.7) | 29.2 (7.8) | 0.64 |
| Comorbidities | ||||||
| Prior MI | 118 (24.8) | 26 (22.0) | 36 (28.3) | 23 (19.3) | 33 (29.7) | 0.46 |
| Prior CAD | 261 (53.7) | 58 (49.2) | 66 (50.8) | 66 (55.0) | 71 (60.2) | 0.07 |
| COPD | 140 (28.8) | 42 (35.6) | 29 (22.3) | 39 (32.5) | 30 (25.4) | 0.30 |
| Anemia | 258 (53.2) | 42 (35.6) | 63 (48.8) | 74 (61.7) | 79 (66.9) | <0.001 |
| Severe renal disease | 81 (17.2) | 4 (3.5) | 16 (12.6) | 25 (21.6) | 36 (31.3) | <0.001 |
| Creatinine clearance (ml/min), mean (SD) | 58.8 (33.9) | 70.2 (33.2) | 61.0 (33.4) | 56.2 (35.0) | 47.7 (30.6) | <0.001 |
| C- Reactive Protein (mg/dL) | 4.34 (6.61) | 2.41 (4.39) | 3.64 (5.48) | 4.39 (6.17) | 7.01 (8.91) | <0.001 |
| Atrial fibrillation/Flutter | 155 (31.9) | 44 (37.3) | 43 (33.1) | 37 (30.8) | 31 (26.3) | 0.07 |
| NYHA class 3 or 4 | 355 (73.0) | 89 (75.4) | 101 (77.7) | 81 (67.5) | 84 (71.2) | 0.20 |
| Charlson Index ≥3 | 316 (66.5) | 64 (54.2) | 83 (65.4) | 87 (73.1) | 82 (73.9) | 0.001 |
| Moderate or severe diastolic dysfunction | 369 (75.9) | 84 (71.2) | 98 (75.4) | 95 (79.2) | 92 (78.0) | 0.17 |
*
All values are reported as n(%) unless otherwise noted
BMI = body mass index, CAD= coronary artery disease, COPD= chronic obstructive pulmonary disease, EF= ejection fraction, MI= myocardial infarction, NYHA= New York Heart Association