Table 2.

Hazard Ratios (95% CI) for Death Associated with TNFα Quartile

	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P value (trend)
	TNFα<1.5 pg/mL	1.5 TNFα<2.1 pg/mL	2.1 TNFα<3.1 pg/mL	TNFα 3.1 pg/mL
Unadjusted	1 (reference)	1.34 (0.82, 2.19)	1.47 (0.89, 2.44)	2..10 (1.30, 3.38)†	0.002
Model 1	1	1.24 (0.76, 2.04)	1.37 (0.83, 2.28)	1.90(1.18, 3.08)†	0.007
Model 2	1	1.46 (0.87, 2.43)	1.57 (0.92, 2.64)	2.37 (1.43, 3.93)†	<0.001
Model 3	1	1.27 (0.75, 2.14)	1.26 (0.73, 2.16)	1.88(1.09, 3.25)*	0.028

Model 1 adjusted for age, sex, and EF

Model 2 adjusted for above plus hypertension, hyperlipidemia, smoking status, body mass index, diabetes mellitus, coronary artery disease, chronic obstructive pulmonary disease, New York Heart Association functional class, atrial fibrillation/flutter

Model 3 adjusted for above plus creatinine clearance, anemia

^*p<0.05;

^†p<0.01