Fig. 5.

The C-terminal hydrophobic motif of PKBα in the “PH-in” conformer is positioned at the apex of the cavity PKBα C-terminal hydrophobic motif HM (orange) interacting with PKBα kinase domain (green) in the “PH-in” conformer. The PH domain is in pink and the PH domain residue Trp 80 is in red. The model shows that two phenyalanines (in yellow) from the sequence F₄₆₉XXF₄₇₂S of HM are found positioned right above the PH-induced cavity in PKBα kinase domain. Ser 473 is represented in cyan and Tyr 474 in magenta