Effect of S1P1 analogs on plasma creatinine after renal IRI. (Left panel) Mouse kidneys were subjected to 32 min ischemia and 24 h reperfusion and treated with vehicle or SEW2871 (0.1, 1 and 10 mg/kg/dose). Values are means ± S.E.M.; n = 5 for each group. *P < 0.05, P < 0.01, ***P < 0.001 compared to vehicle treatment. (Right panel) Mouse kidneys were subjected to 32 min ischemia and 24 h reperfusion and treated with vehicle or FTY720 (24, 48, 240 and 480 μg/kg/dose). Blood was obtained following 24 h of reperfusion and plasma creatinine was assayed. Values are means ± S.E.M.; n = 4 for each group. *P < 0.005 compared to sham; +P < 0.005 compared with vehicle treatment (data redrawn from [62]).