Table 3.
Odds Ratios for Associations of Estrogens and SHBG with Incident Colorectal Cancer
| Hormone | Cases (n=148)* | Controls (n=293)* | Univariate Odds Ratio (95% CI)† | BMI-Adjusted Odds Ratio (95% CI)‡ |
|---|---|---|---|---|
| Estrone Quartiles | ||||
| ≤13 pg/mL (%) | 27 (18.2) | 78 (26.6) | 1.0 (reference) | 1.0 (reference) |
| 14–18 pg/mL (%) | 32 (21.6) | 72 (24.6) | 1.3 (0.7–2.4) | 1.2 (0.7–2.2) |
| 19–25 pg/mL (%) | 45 (30.4) | 75 (25.6) | 1.7 (0.96–3.0) | 1.5 (0.8–2.7) |
| ≥26 pg/mL (%) | 44 (29.7) | 68 (23.2) | 1.8 (1.0–3.3) | 1.6 (0.8–3.0) |
| p-trend=0.03 | p-trend=0.15 | |||
| Continuous scale (log2) | 1.4 (1.1–1.9) | 1.3 (0.96–1.8) | ||
| p-trend =0.02 | p-trend =0.09 | |||
| Estradiol Tertiles | ||||
| ≤6 pg/mL (%) | 31 (29.2) | 66 (31.6) | 1.0 (reference) | 1.0 (reference) |
| 7–9 pg/mL (%) | 44 (41.5) | 81 (38.8) | 1.2 (0.7–2.2) | 1.0 (0.6–1.9) |
| ≥10 pg/mL (%) | 31 (29.2) | 62 (29.7) | 1.1 (0.6–2.2) | 0.8 (0.4–1.7) |
| p-trend=0.81 | p-trend=0.43 | |||
| Continuous scale (log2) | 0.9 (0.6–1.3) | 0.7 (0.5–1.2) | ||
| p-trend =0.70 | p-trend =0.17 | |||
| SHBG Quartiles | ||||
| ≤37 nmol/L (%) | 49 (33.1) | 79 (27.0) | 1.0 (reference) | 1.0 (reference) |
| 38–50 nmol/L (%) | 34 (23.0) | 70 (23.9) | 0.8 (0.5–1.3) | 0.8 (0.5–1.3) |
| 51–66 nmol/L (%) | 36 (24.3) | 69 (23.5) | 0.9 (0.5–1.5) | 1.0 (0.5–1.8) |
| ≥67 nmol/L (%) | 29 (19.6) | 75 (25.6) | 0.6 (0.4–1.1) | 0.8 (0.4–1.4) |
| p-trend=0.13 | p-trend=0.48 | |||
| Continuous scale (square root) | 0.9 (0.8–1.1) | 1.0 (0.8–1.1) | ||
| p-trend =0.18 | p-trend =0.60 | |||
*
All analyses are based on 148 cases and 293 controls except for estradiol which includes 106 cases and 209 controls
†
Adjusted for matching factors only
‡
Adjusted for matching factors and BMI